viagra generico 50 mg prezzo piu basso (Nat Commun, March 2011) Gene expression analysis of early embryos explores the most conserved stages in vertebrate development.
http://cinziamazzamakeup.com/?x=siti-sicuri-per-comprare-viagra-generico-50-mg-pagamento-online Vertebrates have diversified shockingly during evolution (think of a goldfish and a rhinoceros). And for that reason, it is even more stunning how similar their embryos look during development. A recent article by Naoki Irie and Shigeru Kuratani at the RIKEN Center for Developmental Biology in Japan may bring us a little closer to understanding the mechanism behind early (1).
http://cinziamazzamakeup.com/?x=quanto-costa-viagra-generico-100-mg-in-farmacia-a-Milano Most biologists are familiar with Haeckel’s pithy summary of development in evolutionary context: “ontogeny recapitulates phylogeny” – the idea that animal embryos progressively resemble the various evolutionary ancestors of a given species (phylogeny) as they progress through development (ontogeny). This also apply to humans. Although you now look like a person, in the womb you looked like a fish, a tadpole and a mouse at various stages of gestation. This was a handy idea, because it explained how lineages with shared ancestry would have embryos that look so much alike.
lasix ivp used for But Haeckel’s axiom has been somewhat dismissed from the tenets of modern evolutionary developmental (or “evo-devo”) biology. Instead, it is thought that early development is conserved because mutations that cause even the slightest tinkering at this stage can have lethal consequences, and are strongly selected against. In other words, early embryonic development may follow the old adage “if it ain’t broken don’t fix it”. That said, there is still some contention among experts about which are the most conserved developmental stages. Based on , two hypotheses have emerged: the “funnel” model proposes that the strongest developmental conservation will occur during the earliest stages of development, whereas the “hourglass” model places the highest conservation at slightly later stages, when is in full swing.
see url As Irie and Kuratani explain in their article, if animal development is the progressive generation of specialized cell types from a single cell, we can think of developmental conservation as similarities in the formation of equivalent cell types across species. In turn, they argue, conservation in the development of equivalent cell types across species should result in more similar embryo-wide gene expression profiles.
source site Using , Irie and Kuratani profiled the of embryos from four vertebrate species (mouse, chicken, frog and zebrafish) at different comprare viagra generico 50 mg spedizione veloce a Roma stages of early development. By performing an all-to-all pairwase comparison of the transcriptomes, the authors observed a clear tendency for pairs of to be more highly http://cinziamazzamakeup.com/?x=omprare-viagra-generico-100-mg-consegna-rapida-a-Roma correlated. In fact, pharyngula embryos were more highly correlated than all other developmental stages. More importantly, because early developmental stages showed less similarity, the authors conclude that their data support the hourglass over the funnel model of developmental conservation. Moreover, based on a preliminary analysis including transcriptional data from mosquito embryos, the authors argue that such conservation may extend to all animals.
dosaggio levitra generico Why conserve the transcriptomes of pharyngula embryos and not earlier stages? As Irie and Kuratani rightly point out, this observation may only be revealing the process of evolution rather than a particular adaptation that has been strongly selected for (). They argue that the regulatory networks needed to build the basic bilateral body plan may be very sensitive to perturbation and contstrained by prior regulatory states.
source Further research will likely answer this question. In the meantime, it is fascinating that Irie and Kuratani could detect any transcriptional conservation at all. They worked at a very low spatial resolution, trying to capture the formation of relatively scarce cell types against the background of whole embryos. Since the same are often recycled in a combinatorial and context-specific manner to instruct the formation of diverse tissues, it is rather surprising that they could pick up statistically significant signal amid all that “crosstalk”.
order generic levitra professional But they did, and that’s remarkable.
(1) Irie N and Kuratani S. Comparative transcriptome analysis reveals vertebrate phylotypic period during organogenesis. Nat Commun, 2011;2:248. doi:10.1038/ncomms1248.